Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor
نویسندگان
چکیده
منابع مشابه
Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor
Overexpression of protein tyrosine phosphatase PTP4A oncoproteins is common in many human cancers and is associated with poor patient prognosis and survival. We observed elevated levels of PTP4A3 phosphatase in 79% of human ovarian tumor samples, with significant overexpression in tumor endothelium and pericytes. Furthermore, PTP4A phosphatases appear to regulate several key malignant processes...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.23787